Measure
of the total number of leukocytes in whole blood. Counted on automated instruments
using light scattering or electrical impedance after lysis of RBCs. WBCs
are distinguished from platelets by size.
Normal
Range: 3.4-10 K/µL
increased
in: Infection, inflammation, hematologic malignancy, leukemias (AML, ALL,
CML, CLL), lymphoma. Drugs: corticosteroids.
Decreased in: Aplastic
anemia (decreased production), B12 or folate deficiency (maturation defect),
sepsis (decreased survival). Drugs: phenothiazines, chloramphenicol, aminopyrine.
Additional: Spurious
increase: with high number of nucleated red cells.
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