MCHC
describes how fully the erythrocyte volume is filled with hemoglobin and
is calculated from measurement of hemoglobin (Hb), mean corpuscular corpuscular
volume (MCV) and red cell count (RBC); ie, MCHC = Hb/MCV x RBC.
Normal Range: 31-36 g/dL
increased
in: Marked spherocytosis. Spuriously increased in autoagglutination, hemolysis
(with spuriusly high Hb or low MCV or RBC), lipemia. Cellular dehydration
syndromes, xerocytosis.
Decreased in: Hypochromic
anemia (iron deficiency, thalassemia, lead poisoning), sideroblastic anemia,
anemia of chronic disease. Spuriously decreased in high WBC (with spuriously
low Hgb or high MCV or RBC).
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