Platelets
are released from megakaryocytes in bone marrow, and they are important
for adequate hemostasis. Platelet counting is done by flow cytometer based
on size discrimination using either electrical impedance or electro-optical
systems.
Normal Range: 150-450 X 10 3/uL
increased
in: Myeloproliferative disorders: polycythemia vera, CML, essential thrombocythemia,
myelofibrosis, after bleeding, postsplenectomy, reactive thrombocytosis
secondary to inflammatory diseases.
Decreased in: Decreased
production: bone marrow suppression or replacement, chemotherapeutic agents,
other drugs, eg, ethanol. Increased destruction or removal: splenomegaly,
DIC, platelet antibodies (ITP, posttransfusion purpura, neonatal isoimmune
thrombocytopenia, drugs (eg, quinidine, cephalosporins).
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