Monday, March 16, 2015

Platelet Count



Platelets are released from megakaryocytes in bone marrow, and they are important for adequate hemostasis. Platelet counting is done by flow cytometer based on size discrimination using either electrical impedance or electro-optical systems. 


Normal Range: 150-450 X 10 3/uL

increased in: Myeloproliferative disorders: polycythemia vera, CML, essential thrombocythemia, myelofibrosis, after bleeding, postsplenectomy, reactive thrombocytosis secondary to inflammatory diseases. 

 
Decreased in: Decreased production: bone marrow suppression or replacement, chemotherapeutic agents, other drugs, eg, ethanol. Increased destruction or removal: splenomegaly, DIC, platelet antibodies (ITP, posttransfusion purpura, neonatal isoimmune thrombocytopenia, drugs (eg, quinidine, cephalosporins).




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