Plasma
iron concentration is determined by absorption from intestine; storage in
intestine, liver, spleen, bone marrow; rate of breakdown or loss of hemoglobin;
rate of synthesis of new hemoglobin.
Normal Range: 50-175 µg/dL
increased
in: Hemochromatosis, hemosiderosis (eg, multiple transfusions, excess iron
administration), hemolytic anemia, pernicious anemia, aplastic or hypoplastic
anemia, viral hepatitis, lead poisoning, thalassemia. Drugs: dextran, estrogens,
ethanol, oral contraceptives.
Decreased in: Iron
deficiency, nephrotic syndrome, chronic renal failure, many infections,
active hematopoiesis, remission of pernicious anemia, hypothyroidism,
malignancy (carcinoma), postoperative state, kwashiorkor, drugs.
Additional: Used
in evaluation of iron deficiency (see TIBC and Ferritin).
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