Thursday, March 19, 2015

Iron

Plasma iron concentration is determined by absorption from intestine; storage in intestine, liver, spleen, bone marrow; rate of breakdown or loss of hemoglobin; rate of synthesis of new hemoglobin. 


Normal Range: 50-175 µg/dL

increased in: Hemochromatosis, hemosiderosis (eg, multiple transfusions, excess iron administration), hemolytic anemia, pernicious anemia, aplastic or hypoplastic anemia, viral hepatitis, lead poisoning, thalassemia. Drugs: dextran, estrogens, ethanol, oral contraceptives. 
 
Decreased in: Iron deficiency, nephrotic syndrome, chronic renal failure, many infections, active hematopoiesis, remission of pernicious anemia, hypothyroidism, malignancy (carcinoma), postoperative state, kwashiorkor, drugs. 
 
Additional: Used in evaluation of iron deficiency (see TIBC and Ferritin).

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