U/LGGT
is an enzyme present in liver, kidney, and pancreas. It transfers C-terminal
glutamic acid from a peptide to other peptides of L-amino acids. It is induced
by alcohol intake and is an extremely sensitive indicator of liver disease,
particularly alcoholic liver disease.
Normal
Range: Laboratory-specific
increased
in: Liver disease: acute viral or toxic hepatitis, chronic or subacute hepatitis,
cirrhosis, biliary tract obstruction (intrahepatic or extrahepatic), primary
or metastatic liver neoplasm, alcoholic hepatitis, mononucleosis. Drugs
(by enzyme induction): phenytoin, barbiturates, alcohol.
Additional: Useful
in follow up of alcoholics undergoing treatment. Test sensitive to modest
alcohol intake. Test positive in 90% of patients with liver disease. Used
to confirm hepatic origin of elevated serum alkaline phosphatase.
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