Monday, March 16, 2015

Albumin


Major component of plasma proteins, influenced by nutritional state, hepatic function, renal function, various diseases. 

Normal Range: 3.4-4.7 g/dL

increased in: Dehydration, shock, hemoconcentration. 
Decreased in: Decreased hepatic synthesis (chronic liver disease, malnutrition, malabsorption, malignancy, congenital analbuminemia [rare]). Increased losses (nephrotic syndrome, burns, trauma, hemorrhage with fluid replacement, fistulae, enteropathy, acute or chronic glomerulonephritis). Hemodilution (pregnancy, CHF). Drugs (eg, estrogens). 
Additional: Serum albumin gives an indication of severity in chronic liver disease. Useful in nutritional assessment if no impairment in production or increased loss.

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