The
plasma protein concentration is determined by the nutritional state, hepatic
function, renal function, and various disease states and hydration. The
plasma protein concentration determines colloidal osmotic pressure.
Normal
Range: 6-8 g/dL
increased
in: Polyclonal or monoclonal gammopathies, marked dehydration. Drugs: anabolic
steroids, androgens, corticosteroids, epinephrine.
Decreased in: Protein-losing
gastroenteropathies, acute burns, nephrotic syndrome, severe dietary protein
deficiency, chronic liver disease, malabsorption syndrome, agammaglobulinemia.
Additional: The
serum total protein consists primarily of albumin and globulin. Hypoproteinemia
usually means hypoalbuminemia, since albumin is the major serum protein.
Globulin is calculated as total protein minus albumin.
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